Colorectal Cancer:
Conditions
Interventions
Gold Standard:Pathologically confirmed: Colorectal cancer?
Index test:Multimodal combined biomarkers (including CT and MRI: imaging features, values, radiomic parameters
fecal microbiota: diversity, abundance, metabolites
blood: metabolites, inflammatory factors, transcriptome, proteome)
Sponsors
Peking University Cancer Hospital (Beijing Cancer Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Pathologically confirmed colorectal cancer by pre-treatment biopsy; 2. Planned to undergo either direct surgery or neoadjuvant therapy followed by surgery at this hospital; 3. Age >= 18 years.
Exclusion criteria
Exclusion criteria: 1. History of or concurrent primary malignancy at another site; 2. Previous history of any tumor-directed therapy; 3. Unavailable or insufficient pathological information; 4. Incomplete pre-treatment imaging studies or image quality insufficient for evaluation; 5. Pregnancy or lactation; 6. Use of antibiotics or probiotic supplements within one week prior to enrollment; 7. Poor venous access or history of vasovagal reactions to blood draws/needles (needle phobia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Staging of direct surgery and preoperative response evaluation of neoadjuvant or immunotherapy;Adverse events include pain, bruising, or vasovagal reactions related to blood drawing.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Predicting treatment response by combining microbiome features with radiomic parameters;Association between dynamic evolution of the microbiome-metabolism-immune axis and imaging biomarkers;Toxicity dynamics during immunotherapy for colorectal cancer and their negative regulation of tumor response; | — |
Countries
China
Contacts
Public ContactSun Yingshi
Peking University Cancer Hospital (Beijing Cancer Hospital)
Outcome results
None listed