sepsis
Conditions
Interventions
Sepsis Non-ALI Group:None
Healthy control group:None
Psis-induced ALI group:None
Sponsors
Yichang Central People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Sepsis Group: 1. Age >= 18 years; 2. Within 24 hours of admission, meet the Sepsis 3.0 diagnostic criteria in the latest Surviving Sepsis Campaign International Guidelines (i.e., suspected or confirmed infection, with an increase in Sequential Organ Failure Assessment (SOFA) score of >=2 points from baseline in the Acute Physiology and Chronic Health Evaluation II (APACHE II) score); Healthy Control Group: 1. Health check participants matched for age and gender with the sepsis group; 2. No acute or chronic infection, autoimmune disease, malignancy, or major organ dysfunction.
Exclusion criteria
Exclusion criteria: 1. Age 85; 2. Pregnant or breastfeeding women; 3. Long-term use of immunosuppressive drugs (such as corticosteroids, chemotherapy drugs); 4. Suffering from terminal illness (e.g., expected survival <3 months); 5. Unable to obtain informed consent from the patient's family.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative expression level of the TGM2 gene;Relative expression level of the ANKRD55 gene;Relative expression level of the BCL2A1 gene;Relative expression level of the CASP5 gene;Relative expression level of the GRB10 gene;Relative expression levels of the TOP2A gene;Relative expression levels of the KLRD1 gene; | — |
Secondary
| Measure | Time frame |
|---|---|
| SOFA Score;APACHE II Score;Oxygenation Index(PaO2/FiO2); | — |
Countries
China
Contacts
Public ContactJiang Mengbi
Yichang Central People's Hospital
Outcome results
None listed