amnestic mild cognitive impairment
Conditions
Interventions
treatment group: paired-associative stimulation combined with cognitive training
control group:single-target stimulation combined with cognitive training
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. meet the diagnostic criteria for amnestic mild cognitive impairment (aMCI) and have never taken cognitive improvement medication; 2. be >=50 and <=80 years of age, of either sex, and right-handed; 3. complaints of memory loss with objective evidence (long-delayed recall scores on the Auditory Word Learning Test are at least 1.0 standard deviation below the mean of the age-matched population); 4. have a primary school education or higher; 5. understand, agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Concurrent tumours, severe cardiac, hepatic, renal, or haematological disorders, or infectious diseases; 2. History of cerebrovascular disease, Parkinson's syndrome, or dementia of any aetiology; 3. History of anxiety, depression, schizophrenia, or other psychiatric disorders; 4. Severe visual or auditory impairment; 5. Presence of MRI contraindications (e.g., cardiac pacemakers, cardiac stents, artificial heart valves, surgical fixation plates following fracture surgery).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Auditory Verbal Learning Test Fifth Trial ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuropsychological evaluations;Magnetic Resonance Imaging; | — |
Countries
China
Contacts
Public ContactLu Juan-Juan
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese
Outcome results
None listed