Skip to content

Application of Non-Invasive Liver Fibrosis Scores in Oxaliplatin-Related Sinusoidal Obstruction Syndrome in Patients with Gastrointestinal Malignancies

Application of Non-Invasive Liver Fibrosis Scores in Oxaliplatin-Related Sinusoidal Obstruction Syndrome in Patients with Gastrointestinal Malignancies

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500112694
Enrollment
Unknown
Registered
2025-11-18
Start date
2025-12-26
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal Malignancies

Interventions

the high SVI group:None
the low SVI group:None

Sponsors

Linyi Tumor Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients with pathologically confirmed, postoperative stage II-III colorectal or gastric cancer treated with oxaliplatin-containing adjuvant chemotherapy.

Exclusion criteria

Exclusion criteria: 1.The exclusion criteria were as follows: 1) having received less than 3 months of postoperative adjuvant chemotherapy; 2. Incomplete clinical data, laboratory results, or imaging studies; 3. Development of metastasis during adjuvant therapy; 4. Administration of additional chemotherapy drugs; 5. A history of splenectomy; 6. A history of liver cirrhosis, chronic liver disease, or prior liver surgery; 7. Pre-existing hematological diseases that cause platelet abnormalities.

Design outcomes

Primary

MeasureTime frame
aspartase aminotransferase AST to alanine aminotransferase ALT ratio,AAR;fibrosis index based on the 4 factor,FIB-4;r-glutamyl transpeptidase-to-pialelet ratio,GPR;aspartase aminotransferase to platelet retio index,APRI;the volum of spleen;

Countries

China

Contacts

Public ContactMeng Liu

Linyi Tumor Hospital

liu20218866@163.com+86 539 8125128

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026