Chronic pain
Conditions
Interventions
Control group:None
Patient group:None
Sponsors
Shenzhen Nanshan District People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Case group 1.Aged 18 and above, meeting the clinical diagnostic criteria for PHN (persistent pain for at least 3 months after healing of herpes zoster rash ), currently experiencing significant pain symptoms (such as visual analog scale (VAS) >=40/100 mm); 2.With a disease duration of over 3 months. Conscious and able to cooperate with MRI, EEG examination, and questionnaire assessment. Healthy Control Group 1. Age and gender are basically matched with the patient group; 2. No history of chronic pain such as postherpetic neuralgia, fibromyalgia, or headaches; 3. No history of neurological, psychiatric, or serious physical diseases; 4. Not taking medications long-term that may affect central nervous system function; 5. Voluntarily participate in this study and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Individuals with severe comorbidities (such as decompensated cardiac, hepatic, or renal insufficiency) or unstable internal diseases who are unable to tolerate research examinations. - Individuals with neurological disorders (such as stroke, epilepsy, Parkinson's disease) or severe mental disorders (such as schizophrenia) that may affect brain imaging and electroencephalogram (EEG) results. - Patients with severe depression or anxiety disorders who are undergoing acute treatment (mild emotional symptoms are not a basis for exclusion, but their impact needs to be controlled in data analysis). 2,MRI contraindications: individuals with cardiac pacemakers, metal implants or fragments, cochlear implants, etc. in the body;Individuals with severe claustrophobia or other reasons who cannot undergo MRI scanning. EEG contraindications or influencing factors: individuals with extensive scalp damage or infection that prevents electrode placement; 3.Individuals who have taken drugs that may significantly affect brain electrical activity (such as benzodiazepines, antiepileptic drugs) within the past 24 hours and cannot discontinue them. 4.Pregnant or lactating women: due to the potential uncertain effects of MRI on the fetus, pregnant women are not included in the study; Lactating women need to be evaluated for risks before deciding whether to be included. 5.Other situations deemed unsuitable for participation in the study by the researcher, such as poor compliance and inability to cooperate with the entire research process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vas score; | — |
Countries
China
Contacts
Public ContactJiang Changyu
Shenzhen Nanshan District People's Hospital
Outcome results
None listed