Diet-related metabolic alterations
Conditions
Interventions
AB Group (Pre-prepared meal diet ? Whole-food diet):Participants will first receive 14 days of Chinese-style pre-prepared meal diet (Phase A), followed by a 28-day washout period, and then receive 14
breakfast is standardized across both phases.
BA Group (Whole-food diet ? Pre-prepared meal diet):Participants will first receive 14 days of freshly cooked whole-food diet (Phase B), followed by a 28-day washout period, and then receive 14 days o
Sponsors
Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Male or female, aged 18–35 years; 2. Body mass index (BMI) between 20 and 35 kg/m²; 3. Body weight stable within the past 3 months (change <5%); 4. Generally healthy, with no history of diabetes, metabolic syndrome, gastrointestinal diseases, or major surgery; 5. No use of antibiotics, probiotics, or medications affecting gut microbiota within the past 3 months; 6. Willing to participate and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with diabetes, fatty liver disease, hypertension, metabolic syndrome, or other chronic metabolic disorders; 2. Long-term use of glucose-lowering drugs, lipid-lowering agents, hormones, or immunosuppressants; 3. Pregnant, breastfeeding, or planning pregnancy during the study period; 4. Food allergies or specific dietary restrictions (e.g., vegetarianism, lactose intolerance); 5. Unable or unwilling to comply with dietary interventions or biological sample collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total cholesterol;triglycerides; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bile acid profiles;Microbial-derived metabolites; | — |
Countries
China
Contacts
Public ContactJingxin Li
Shandong University
Outcome results
None listed