Postoperative Fatigue Syndrome (POFS)
Conditions
Interventions
Remimazolam-Lidocaine group:Remimazolam combined with lidocaine
Remimazolam-Sufentanil group:Remimazolam combined with sufentanil
Remimazolam-Esketamine group:Remimazolam combined with esketamine
Ciprofol-Lidocaine group:Ciprofol combined with lidocaine
Ciprofol-Sufentanil group:Ciprofol combined with sufentanil
Ciprofol-Esketamine group:Ciprofol combined with Esketamine
Propofol-Lidocaine group:Propofol combined with lidocaine
Propofol-Sufentanil group:Propofol combined with sufentanil
Propofol-Esketamine group:Propofol combined with esketamine
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients who are scheduled to undergo painless gastrointestinal endoscopy; 2.Age >= 45 years old; 3.ASA physical status I-II; 4.Signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1.BMI > 30 kg/m^2; 2.Cardiovascular and cerebrovascular diseases (history of myocardial infarction, history of stroke, COPD or asthma within 3 months); 3.Impaired liver or kidney function (AST/ALT > 2 times the upper limit, serum creatinine > 1.5 times the upper limit); 4.Epilepsy, mental disorders; 5.Allergic to the studied drug; 6.Unable to cooperate in completing the rating scale.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative fatigue; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypotension and hyoxemia; | — |
Countries
China
Contacts
Public ContactPeng Ke
The First Affiliated Hospital of Soochow University
Outcome results
None listed