Metastatic differentiated thyroid cancer
Conditions
Interventions
Discontinue medication:Levothyroxine withdrawl for 4 weeks? TSH > 30 mIU/L
Day 3: Oral administration of iodine-131 (200 mCi)
LT4 was restored 24 hours after taking the iodine.
Recombinant Human Thyrotropin Injection:Take LT4 throughout the treatment
Day 1-2: Intramuscular injection of rhTSH 0.9mg in the buttocks
Day 3: Oral administration of iodine-131 (200mCi) for oncolytic therapy.
Sponsors
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18 - 75 years old; 2. Patients with differentiated thyroid cancer confirmed by pathology and scheduled for RAI treatment for the first time; 3. Underwent total or near-total thyroidectomy; 4. With distant measurable metastatic lesions indicated by biopsy or imaging examinations (including ultrasound, iodine-131 whole-body scan, CT, MRI or PET/CT); 5. Capable of making decisions and voluntarily participating in this clinical study, and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who are breastfeeding or pregnant; 2. Those with malignant tumors other than differentiated thyroid cancer; 3. Patients not in a TSH suppression state; 4. Patients unable to comply with radiation protection requirements; 5. Those with an expected survival period of less than 6 months; 6. Those allergic to rhTSH or its excipients; 7. Those who have used iodine contrast agents within one month before the surgery or have not followed a low-iodine diet within two weeks before the surgery; 8. Other patients considered unsuitable for participating in this clinical study by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Remission Rate;CT indicators;The shrinking effect of a single iodine-31 treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Thyroid function;Thyroglobulin;Renal function;Lipid profile;Thyroglobulin antibodies;Lodine-131 whole body scan + SPECT/CT indicators; | — |
Countries
China
Contacts
Public ContactLibo Chen
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed