Anti-interferon-? autoantibody syndrome
Conditions
Interventions
Observation group (Patients with clinically confirmed anti-interferon-? autoantibody syndrome):None
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. Patients diagnosed with anti-interferon-? autoantibody syndrome; (1)The diagnosis of Anti-interferon-? Autoantibody syndrome is based on the increased titer of anti-interferon-? autoantibody (AIGA) and positive neutralization test (BLI, flow cytometry, Elisa). 3. Patients complicated with opportunistic pathogens such as Talaromyces marneffei and non-tuberculous mycobacteria, and with prolonged disease course and disseminated infection; 4. Written informed consent was obtained before the study.
Exclusion criteria
Exclusion criteria: 1. Patients with other possible congenital or secondary immunodeficiency; 2. Not fit to participate in the study according to the investigator's judgment; 3. Suspected or real history of alcohol or drug abuse; 4. Those who did not sign the informed consent; 5. Participants deemed unsuitable by other investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence rate;Level of geographical distribution;Common risk factors;Clinical Features; | — |
Secondary
| Measure | Time frame |
|---|---|
| The titer of AIGA;Clinical picture;Imaging findings;Changes in laboratory tests; | — |
Countries
China
Contacts
Public ContactYe Feng
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed