Uterine fibroids
Conditions
Interventions
Shortened interpregnancy interval group:Short-term contraception for 6 months following myomectomy
Conventional Interpregnancy Interval Group:12-month contraception after myomectomy
Sponsors
International Peace Maternity & Child Health Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Subjects must meet all of the following criteria to be enrolled in the study: (1) Age 20-45 years; (2) 6-8 weeks after undergoing myomectomy (laparoscopic/laparotomy/hysteroscopic) with confirmed absence of postoperative complications such as infection or hemorrhage; (3) FIGO type I-VI leiomyomas, and the myomectomy procedure did not involve full-thickness penetration of the uterine wall; (4) Have a clear desire for future pregnancy and wish to conceive within 2 years after surgery; (5) Normal uterine cavity morphology post-surgery; (6) Signed informed consent.
Exclusion criteria
Exclusion criteria: Subjects meeting any of the following criteria will be excluded from the study: (1) FIGO type 0 or VII leiomyomas, full-thickness uterine penetration during myomectomy, or diffuse uterine leiomyomatosis; (2) Coexisting untreated intrauterine adhesions, endometriosis stage III-IV (ASRM classification), tubal obstruction, or ovarian insufficiency; (3) Presence of severe medical comorbidities, active autoimmune disease, or history of malignancy; (4) History of thromboembolic disease, hormone-dependent tumors, or uncontrolled hepatic dysfunction constituting a clear contraindication to surgery; (5) Established pregnancy; (6) Planned participation in other clinical trials involving reproductive interventions, or use of long-acting hormonal medications within the past 3 months; (7) Inability to comply with follow-up or refusal to use the prescribed contraceptive regimen.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of myomectomy-associated adverse pregnancy outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative live birth rate;Natural conception rate;Miscarriage rate;Cesarean section rate;Clinical pregnancy rate; | — |
Countries
China
Contacts
Public ContactXu Hong
International Peace Maternity and Child Health Hospital
Outcome results
None listed