Infection with carbapenem-resistant Enterobacterales (CRE) or carbapenem-resistant Pseudomonas aeruginosa (CRPA)
Conditions
Interventions
Blood concentration observation group blood concentration observation group:None
Sponsors
Tongde Hospital of Zhejiang Province
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients clinically diagnosed with or highly suspected of having carbapenem-resistant Enterobacteriaceae (CRE) or carbapenem-resistant Pseudomonas aeruginosa (CRPA) infections; 2.Aged 18 years or older, regardless of gende; 3.Received ceftazidime-avibactam treatment for a duration of =72 hours; 4.Provided informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients allergic to any component of ceftazidime-avibactam for injection; 2.Pregnant or lactating women; 3.Patients who are deemed by the investigator to be unable to complete the study follow-up; 4.Microbial culture results confirmed insensitivity to CZA;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Security Index;TDM target attainment rate;14-day or 28-day mortality rate;Microbial reaction; | — |
Countries
China
Contacts
Public ContactYuexing Tu
Tongde Hospital of Zhejiang Province
Outcome results
None listed