Sepsis
Conditions
Interventions
Persistent Inflammation-Immunosuppression Catabolism Syndrome:None
Sponsors
Shiyan Taihe Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: **Healthy Control (HC) Group:** 1. Age >= 65 years; 2. No active infection, immune diseases, or related medication history; 3. Written informed consent obtained from the patient or their legal representative. **Sepsis Patients:** 1. Age >= 65 years; 2. Meet the Sepsis 3.0 International Consensus diagnostic criteria: Infection + SOFA score (Cardiovascular SOFA =1 point, or SOFA score =2 points in other organ systems); 3. Written informed consent obtained from the patient or their legal representative. **Persistent Inflammation-Immunosuppression Catabolism Syndrome (PICS) Patients:** 1. ICU stay >= 14 days; 2. C-reactive protein (CRP) > 150 mg/dL; 3. Lymphocyte count (LYM) 10% during the hospital stay or Body Mass Index (BMI) < 18 kg/m².
Exclusion criteria
Exclusion criteria: 1. Individuals with immune deficiency; 2. Patients receiving immunomodulatory therapy: including chronic use of prednisone (or equivalent corticosteroids), chemotherapy, or biological immunomodulators (e.g., immunosuppressants); 3. Other factors: Patients with sepsis attributed to other causes such as cancer or trauma (the study focuses specifically on sepsis following bacterial infection).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| endocannabinoid expression level;Treg/Th17 cell ; | — |
Countries
China
Contacts
Public ContactKe Xianting
Shiyan Taihe Hospital
Outcome results
None listed