pain
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age range: 80-100years old; 2.ASA classification II-III; 3.First unilateral total hip replacement surgery under general anesthesia; 4.The patient or their family members sign an informed consent form;
Exclusion criteria
Exclusion criteria: 1. Severe cognitive impairment before surgery (MMSE score < 24) or inability to communicate; 2. Long-term use of opioid analgesics or history of drug abuse; 3. Allergy to the local anesthetics used in the study (such as ropivacaine); 4. Infection at the puncture site, peripheral neuropathy, or severe coagulation disorders; 5. Severe liver or kidney dysfunction (Child-Pugh class C or eGFR < 30 ml/min); 6. Presence of other diseases that may severely affect immunity or stress response (such as advanced cancer, autoimmune diseases, or long-term use of glucocorticoids).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain level in resting or exercise state;Postoperative cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| immune function;stress response; | — |
Countries
China
Contacts
Southwest Medical University Affiliated Hospital