Cesarean Delivery
Conditions
Interventions
Continuous Norepinephrine group:Prophylactic Intravenous Infusion of Norepinephrine (4 µg/mL, 0.05 µg·kg?1·min?1) After Spinal-Epidural Anesthesia
Bolus Norepinephrine group:Intermittent Intravenous Bolus Injection of Norepinephrine Solution (4 µg/mL) Based on Patients' Blood Pressure After Neuraxial Anesthesia
Sponsors
Shanghai General Hospital Jiuquan Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Aged 18–45 years; singleton gestation >=36 weeks,; scheduled for elective cesarean section under combined spinal-epidural anesthesia (CSEA); American Society of Anesthesiologists (ASA) physical status classification Grade ?–?; willing to participate in this trial and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Presence of contraindications related to neuraxial anesthesia; (2) Allergy to any drug used in this study; (3) Recent use of vasoactive drugs; (4) Complicated with hypertension or diabetes mellitus; (5) Known fetal malformation or occurrence of fetal distress; (6) Complicated with varicose veins or a history of bleeding; (7) Complicated with liver or renal impairment; (8) Inability or refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nausea and Vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypotension;Hypertension;bradycardia;respiratory depression;Overall stability of heart rate (HR) and systolic arterial blood pressure (SBP) relative to baseline values ;Umbilical arterial blood gas analysis values;1-minute Apgar scores of the fetus after delivery;5-minute Apgar scores of the fetus after delivery;Dosage of norepinephrine;Dosage of additional local anesthetics for epidural anesthesia;Dosage of atropine;Urine output;Incidence of surgical adverse reactions: traction response, chest tightness, shoulder pain, etc;Incidence of anesthetic adverse reactions: headache, hypothermia;Operation time;time from neuraxial anesthesia to fetal delivery; | — |
Countries
China
Contacts
Public ContactYuan Yuan
Shanghai General Hospital Jiuquan Hospital
Outcome results
None listed