Advanced liver cancer with malignant ascites
Conditions
Interventions
Liver cancer with malignant ascites:None
Sponsors
Chongqing University Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Histopathologically or cytologically confirmed primary liver cancer in advanced stage with malignant ascites. 2. Aged 18-75 years with the ability to tolerate procedures such as abdominal paracentesis and ascitic fluid aspiration. 3. Written informed consent obtained from the patient or their legal representatives, with willingness to participate in the study including provision of relevant clinical information and compliance with scheduled follow-up visits.
Exclusion criteria
Exclusion criteria: 1. Concurrent malignancies that may interfere with liver cancer organoid construction or confound study results. 2. Severe cardiac, hepatic, or renal dysfunction precluding tolerance of study procedures or potentially compromising organoid viability. 3. Prior immunotherapy, targeted therapy, or chemotherapy within 3 months, potentially altering tumor cell biological properties. 4. Psychiatric illness or cognitive impairment preventing study compliance. 5. Pregnancy or lactation due to potential fetal or infant risk. 6. Any other conditions considered by investigators to be unsuitable for study enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Organoid culture success rate;Concordance between organoids and primary tumors;Correlation between drug sensitivity testing results and clinical efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Organoid construction time;Stability of the maintenance state; | — |
Countries
China
Contacts
Public ContactGong Yi
Chongqing University Cancer Hospital, China
Outcome results
None listed