Osteoporosis
Conditions
Interventions
Trial Group:30 cases of high fracture risk patients after surgery for differentiated thyroid carcinoma: treated with zoledronic acid injection, calcium supplements, and active vitamin D. The intervent
Control Group 1:30 cases of high fracture risk patients after surgery for differentiated thyroid carcinoma: treated with calcium supplements and active vitamin D. The intervention period was 1 year, w
Control Group 2:30 cases of other osteoporosis patients: treated with zoledronic acid injection, calcium supplements, and active vitamin D. The intervention period was 1 year, with follow-up conducted
Sponsors
The 960th hospital of the Joint Logistics Support Force of the People's Liberation Army
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis of differentiated thyroid carcinoma with postoperative TSH-suppressive therapy for >=6 months after total thyroidectomy; 2. Non-thyroid cancer osteoporosis patients (control group) without prior malignancy-related surgery; 3. Age >=20 years, with normal cognitive function to comprehend study requirements, physically ambulatory, and committed to completing follow-up visits; 4. Voluntary participation with written informed consent obtained after full disclosure of study objectives and risks.
Exclusion criteria
Exclusion criteria: ??1.Patients with diseases affecting bone metabolism?? were excluded, including type 1 diabetes mellitus, parathyroid disorders, and other endocrine/metabolic diseases such as renal disease, hypopituitarism, or Cushing’s syndrome.2.??Patients with systemic autoimmune diseases?? ??or neoplastic diseases?? were excluded.3.??Patients who had already initiated anti-osteoporotic medications?? were excluded.4.??Patients using medications that interfere with bone metabolism?? were excluded.5.??Pregnant or lactating women??, ??or women planning pregnancy?? during the study period, were excluded.6.Patients unwilling to comply with the study protocol?? or unable to complete follow-up assessments were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone mineral density; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bone metabolism; | — |
Countries
China
Contacts
Public ContactQu Wei
The 960th hospital of the Joint Logistics Support Force of the People's Liberation Army
Outcome results
None listed