Mild cognitive impairment
Conditions
Interventions
Test group:Take 4 ergotamine capsules daily, 2 in the morning and 2 in the evening, continuously for 24 weeks.
Sponsors
Chaohu Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Participants were informed of the experimental content and purpose, and signed an informed consent form. 2) Self-reported at least two symptoms (such as short-term memory decline, distraction, or decreased executive function) lasting >=3 months, and did not meet the diagnostic criteria for neurodegenerative diseases. 3) Montreal Cognitive Assessment (MoCA) score between 18 and 26 points (for those with 0.4 pg/mL.
Exclusion criteria
Exclusion criteria: 1) Significant cognitive decline, such as in patients with Alzheimer's disease (AD); 2) Currently undergoing chemotherapy/radiotherapy, or having disabilities or difficulties in hearing, vision, or communication; 3) Pregnant or breastfeeding women, or those planning to conceive within the next 3 months; 4) History or clinical signs of neurological or psychiatric disorders, such as brain tumors, major depression, schizophrenia, etc.; 5) Presence of serious cardiovascular, liver, kidney, or hematological diseases; 6) Recent ( <= 3 months) use of medications affecting cognition (e.g., cholinesterase inhibitors, sedative-hypnotics, antipsychotics); 7) Allergic to ergothioneine, maltodextrin, or other excipients used in the trial; 8) Participation in other similar clinical trials within the past 3 months; 9) Poor compliance or prone to being lost to follow-up; 10) Other conditions deemed unsuitable for participation in the trial by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological Test Battery (NTB) Z-score;; Repeatable Battery for the Assessment of Neuropsychological Status (RBANS);; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in Z-scores in specific areas (based on NTB sub-items);Montreal Cognitive Assessment (MoCA);Mini-Mental State Examination (MMSE);Clinical Dementia Rating Scale (CDR-SB); | — |
Countries
China
Contacts
Public ContactZhang Kai
Chaohu Hospital of Anhui Medical University
Outcome results
None listed