Intraoperative hypotension (IOH)
Conditions
Interventions
Control Group:Standard Care Group
Intervention Group:HPI-guided hemodynamic management
Sponsors
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 65; 2.Scheduled for major abdominal surgery with planned AICU admission, and an anticipated procedure duration of >=2 hours and hospital stay of >=3 days; 3.To undergo invasive arterial blood pressure monitoring; 4.Willingness to participate in the study and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.Refusal to participate in the study; 2.History of chronic alcoholism or substance dependence; 3.Severe cognitive impairment prior to surgery, as indicated by an MMSE score of 133 µmol/L, or ongoing dialysis; inability for self-care prior to surgery; 5.Cerebrovascular accident, myocardial infarction, or unstable angina within the past 3 months; 6.Severe hepatic dysfunction; 7.Neurological disorders, including dementia, Parkinson's disease, history of stroke with cognitive impairment, or long-term use of antipsychotic medications; 8.Surgery within the past 3 months; participation in another clinical trial within the past 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in TWA between the two groups.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain scores within 48 hours after surgery;The recovery rate of gastrointestinal function within 72 hours after surgery;Extubation time and AICU length of stay;The incidence of PONV within 48 hours after surgery;Myocardial Injury after Non-Cardiac Surgery (MINS);Postoperative Acute Kidney Injury (Postoperative AKI);Types of Intraoperative Hypotension;Postoperative Delirium (POD);The incidence and severity of IOH events; | — |
Countries
China
Contacts
Public ContactXiaoping Gu
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Outcome results
None listed