Spinal cord injury
Conditions
Interventions
Cortex-Basal Ganglia Dual-Target (CBDT) Modulation Group:Dual-target TMS stimulation
Sham Group:Sham TMS stimulation
Cortical Single-Target Group:M1 Single-Target TMS Stimulation
Sponsors
Kunshan Rehabilitation Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-50 years; 2. Diagnosed with spinal cord injury via X-ray, CT, or MRI, with stable condition and beyond the spinal shock phase; 3. ASIA Impairment Scale Grade C or D; 4. Absence of other neurological disorders (e.g., Parkinson's disease, Alzheimer's disease); 5. No prior brain neuromodulation treatments received before enrollment.
Exclusion criteria
Exclusion criteria: 1.Presence of cognitive impairment (MMSE score < 25) preventing cooperation with examinations; 2. Contraindications for transcranial magnetic stimulation: cardiac pacemaker, intracranial metal implants, history of epilepsy, or pregnancy; 3. Systemic diseases affecting lower limb joints (e.g., diabetes, thyroid disorders); 4. Comorbid severe cardiac, pulmonary, or hepatic diseases with unstable vital signs; 5. Contraindications specific to TMS stimulation or assessment procedures; 6. Pre-existing conditions causing lower limb motor dysfunction or residual symptoms.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Surface electromyography iEMG and RMS;Motor Evoke Potential;Single-Joint Isokinetic Strength of Basic Motor Functions;Central motor conduction time;Seated balance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cortical silent period;Motor threshold; | — |
Countries
China
Contacts
Public ContactKun Wang
Kunshan Rehabilitation Hospital
Outcome results
None listed