Acute myocardial infarction
Conditions
Interventions
TaVNS group:Upon arrival in the catheterization laboratory, right auricular vagus nerve stimulation therapy was initiated immediately. The stimulation parameters were as follows: frequency 20Hz, pulse
Control group:Conventional coronary intervention, sham stimulation treatment (power on, indicator light display, wearing ear electrode, no current). All patients received standardized coronary heart d
Sponsors
Shanghai Jiao Tong University School of Medicine Affiliated Songjiang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed clinically with STEMI occurring within 24 hours and planning to undergo PCI surgery; (2) Age range: 18-80 years old; (3) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Congenital heart disease, history of myocardial infarction, severe valvular heart disease, known renal failure (GFR<30ml/min), atrial fibrillation, pacemaker patients; (2) Known active malignant tumor diseases; (3) Unable to cooperate with treatment for serious mental illness; (4) There are situations where ear skin damage or infection affects the implementation of taVNS; (5) Pregnant women or women who are planning to conceive in the next 6 months; (6) Patients with a life expectancy of less than 6 months; (7) The researchers believe that patients who are not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative flow ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of inflammatory markers (IL-6, IL-1ß, TNF-a, CRP) were measured 24 hours after surgery.;Cardiac troponin T(cTnT), creatine kinase isoenzyme (CK-MB), and cardiac troponin T(CTNT) were measured at admission and 24 hours after operation. N-terminal pro-B-type natriuretic peptide (NT-proBNP);The values of heart rate and blood pressure before and after each treatment were recorded, and the mean value, standard deviation (SD), coefficient of variation (CV(%)=SD/ mean *100%), fluctuation range d= maximum value -minimum value, and blood pressure variability and heart rate variability were analyzed;Myocardium was assessed by CMR at 7 days and 6 months after surgery Salvage score (MSI), six-minute walk distance (6WMD), quality of life (SF-36); | — |
Countries
China
Contacts
Public ContactLei Hou; Haiyan Shi
Shanghai Jiao Tong University School of Medicine Affiliated Songjiang Hospital
Outcome results
None listed