Condylar resorption
Conditions
Interventions
Control group:None
Exposure group:None
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
12 Years to 20 Years
Inclusion criteria
Inclusion criteria: 1.Age: 12 to 20 years old (inclusive of 12 and 20 years old); 2.The patient require to extract the lower impacted third molar; 3.The patient was confirmed by joint MRI diagnosis that one side was a normal joint and the other side had idiopathic condylar resorption (Young's grade 2 or above). 4.The patient voluntarily participated in the study, could cooperate with the examination and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.The patient has obvious oral abscesses, precancerous lesions, fungal infections and pericoronitis of wisdom teeth throughout the mouth. 2.The patient has at least one of the following diseases: juvenile idiopathic arthritis and osteoarthritis, autoimmune diseases, endocrine disorders, anorexia nervosa, diabetes and thyroid diseases; 3.The patient has a history of intravenous use of bisphosphonates. 4.The patient uses immunosuppressants; 5.The patient has coagulation dysfunction, thrombocytopenia, hemophilia or significant anemia. 6.The patient has malignant tumor. 7.The patients diagnosed with acquired immunodeficiency syndrome, syphilis, hepatitis B and hepatitis C, who have not received standardized treatment and control; 8.According to the researcher's judgment, the patient has other factors that may affect the research results or lead to the forced termination of this study halfway, such as pregnancy, lactation, alcohol abuse, drug abuse, other serious diseases (including mental illness) requiring combined treatment, severe laboratory test abnormalities, accompanied by family or social factors, etc., which will affect the patient's safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main differential genes of the alveolar bone between the affected side and the healthy side.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The differential protein enrichment pathways of alveolar bone between the affected side and the healthy side;The differential gene enrichment pathways of alveolar bone between the affected side and the healthy side.; | — |
Countries
China
Contacts
Public ContactJing Ge
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed