leprosy
Conditions
Interventions
Gold Standard:clinical diagnosis of leprosy according to WHO criteria, supported by neurological examination nerve conduction studies (NCS) and ultrasonographic assessment of peripheral nerves
Index test:measurement of anti- LID1 antibodies using ELISA for early detection of sub-clinical M. leprae infection among household contacts. Anti- LID1 antibody ELISA diagnostic test
Sponsors
Faculty of Medicine, Sohag University
Eligibility
Sex/Gender
All
Age
5 Years to 60 Years
Inclusion criteria
Inclusion criteria: household contacts of clinically confirmed leprosy patients Both genders participants who provide informed written consent
Exclusion criteria
Exclusion criteria: 1.Known peripheral neuropathy from other causes (e.g., diabetes, alcoholic neuropathy, autoimmune diseases such as rheumatoid arthritis) 2.Immunocompromised individuals(e.g. HIV,chronic renal failure ,chronic liver failure) 3.Systemic infections(e.g. HIV, tuberculosis, hepatitis c ,cutaneous leishmaniasis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serological, neurological evaluation of household contacts;Accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity; | — |
Countries
Eygpt
Contacts
Public ContactDoaa Omar Mohammed
Faculty of Medicine, Sohag University
Outcome results
None listed