Sedation
Conditions
Interventions
AB group:First receive propofol sedation, followed by remimazolam sedation after a washout period of at least 1 week.
BA group:First receive remimazolam sedation, followed by propofol sedation after a washout period of at least 1 week.
Sponsors
Sanming First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Healthy volunteer. 2. Aged 18 to 45 years old. 3. American Society of Anesthesiologists (ASA) physical status I.
Exclusion criteria
Exclusion criteria: 1. Known hypersensitivity or allergy to the investigational drug. 2. History of chronic alcohol or substance abuse (including benzodiazepines or opioids). 3. Intake of medications affecting the central nervous system within 72 hours prior to enrollment. 4. A history of neurological or psychiatric disorders. 5. Women who are pregnant, lactating, or currently menstruating. 6. Any condition that may interfere with study outcomes, such as language comprehension difficulties or communication barriers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The bispectral index during the deep sedation phase ; | — |
Secondary
| Measure | Time frame |
|---|---|
| The bispectral index at the loss of eyelash reflex ;The bispectral index during the moderate sedation phase ;Cognitive function;Emergence time; | — |
Countries
China
Contacts
Public ContactHuifen Lin
Sanming First Hospital
Outcome results
None listed