None
Conditions
Interventions
Observation group:Slowly inject remimazolam at a dose of 0.2 mg/kg intravenously. The maintenance dose is 0.6 mg/kg/h. At the same time, administer remifentanil for injection at a rate of 0.1 µg/(kg·m
Control group:Dexmedetomidine was intravenously infused at a rate of 1 µg/kg for 10 minutes, followed by continuous infusion at a rate of 0.5 µg/(kg·h), while at the same time, the injectable fentanyl
Sponsors
Shenzhen Longgang District Third People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) The patient voluntarily agreed to participate in this study and signed the informed consent form. 2) The patient is over 18 years old, has smooth language communication, and has no obvious hearing or visual impairments. 3) Meets the diagnostic criteria for benign thyroid nodules in Western medicine and is scheduled to undergo thyroid thermocoagulation surgery. 4) American Society of Anesthesiologists (ASA) classification is I - II level.
Exclusion criteria
Exclusion criteria: The patient will be excluded if any of the following criteria are met. 1) The patient refuses to participate in this study or has not signed the informed consent form. 2) The patient has chronic diseases such as hypertension, diabetes, and asthma that were not well controlled before the surgery or have experienced complications. 3) The patient is a long-term user of opioid drugs. 4) The patient has sleep apnea syndrome. 5) The patient has mental disorders or intellectual disabilities that prevent cooperation and normal communication. 6) The patient is an alcoholic. 7) Other situations that the researchers consider unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effectiveness of perioperative drug use;The safety of perioperative drug use;Immune function changes in perioperative patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Record the number of times additional analgesic and sedative drugs were administered during the surgery.;Record the occurrence of adverse reactions such as bradycardia, hypotension, dizziness, headache, respiratory depression, nausea and vomiting during the perioperative period.;Drug residual effects, such as dizziness, restlessness, hallucinations, etc.; | — |
Countries
China
Contacts
Public ContactYan Shen
Shenzhen Longgang District Third People's Hospital
Outcome results
None listed