Depression
Conditions
Interventions
MECT combined with conventional antidepressant treatment group:None
Conventional antidepressant treatment group:None
Sponsors
Beijing Anding Medical Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.MECT Combined with Medication Group - Inclusion Criteria: (1)Aged 16–45 years; (2)Meets the diagnostic criteria for a depressive episode according to DSM-5; (3)Scores >0 on the Scale for Suicide Ideation (SSI); (4)Has not received physical therapies such as MECT or transcranial magnetic stimulation within the past two weeks; (5)MECT is clinically recommended, and the patient or their guardian has provided written informed consent for MECT; (6)Able to cooperate with completing MRI examinations and cognitive function assessments; (7)Written informed consent is obtained from the patient or their family members. 2.Antidepressant Medication Group - Inclusion Criteria: (1)Aged 16–45 years; (2)Meets the diagnostic criteria for a depressive episode according to DSM-5; (3)Scores >0 on the Scale for Suicide Ideation (SSI); (4)Has not received physical therapies such as MECT or transcranial magnetic stimulation within the past two weeks; (5)Able to cooperate with completing MRI examinations and cognitive function assessments; (6)Written informed consent is obtained from the patient or their family members.
Exclusion criteria
Exclusion criteria: 1.MECT Combined with Medication Group - Exclusion Criteria: (1)History of cranial diseases, brain injury, epileptic seizures, or other neurological disorders; (2)History of severe systemic diseases, including cardiovascular, respiratory, or immune system diseases; (3)History of alcohol or opioid abuse; (4)Allergy to both propofol and etomidate, or allergy to succinylcholine; other contraindications to MECT; (5)Pregnancy, lactation, or other somatic conditions affecting the secretion of estradiol, testosterone, or cortisol; (6)Contraindications to MRI scanning, such as implanted cardiac pacemakers or arterial clips. 2.Antidepressant Medication Group - Exclusion Criteria: (1)History of cranial diseases, brain injury, epileptic seizures, or other neurological disorders; (2)History of severe systemic diseases, including cardiovascular, respiratory, or immune system diseases; (3)History of alcohol or opioid abuse; (4)Pregnancy, lactation, or other somatic conditions affecting the secretion of estradiol, testosterone, or cortisol; (5)Contraindications to MRI scanning, such as implanted cardiac pacemakers or arterial clips.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Suicide remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of depressive symptoms; | — |
Countries
China
Contacts
Public ContactYanping Ren
Beijing Anding Medical Hospital, Capital Medical University
Outcome results
None listed