Bone tuberculosis
Conditions
Interventions
Joint tuberculosis Group:None
Sponsors
Shanghai Public Health Clinical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosed with bone or joint tuberculosis (spine, hip, knee, etc.) by pathology or microbiology; 2. No age or gender restrictions; 3. Receiving regular anti-tuberculosis drug treatment, with a regimen that includes isoniazid (patients must have taken oral medication for at least 4 weeks before surgery, and isoniazid will be administered intravenously after admission); 4. Planned to undergo surgical treatment with clear surgical indications; 5. Signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding women; 2. Those with a severe allergy to isoniazid; 3. Individuals with severe mental illness or those unable to comply with follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drug concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cmax;Tmax;Bone/Blood AUC ratio;Peak Penetration Factor, PF; | — |
Countries
China
Contacts
Public ContactChengxiang Li
Shanghai Public Health Clinical Center
Outcome results
None listed