Acute respiratory distress syndrome (ARDS)
Conditions
Interventions
APRV/LTV observation group:None
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Meets the diagnostic criteria of the new global definition of ARDS in the 2023 edition; 2.Age: 18-80 years; 3.PaO2/FiO2 =5cmH2O); 4.Within 24 hours of invasive mechanical ventilation; 5.The patient or the patient's family is asked to agree to participate in the trial and to sign an informed consent form;
Exclusion criteria
Exclusion criteria: 1.Age 80 years; 2.Haemodynamic instability that still requires continuous fluid resuscitation; 3.Increased intracranial pressure. 4.Cervical and spinal injuries requiring immobilisation. 5.Postoperative orthopaedic postural restriction. 6.Recent abdominal surgery requiring restriction of position or severe burns to the ventral region; 7.Maternity. 8.Postoperative facial trauma. 9.There are contraindications related to the application of EIT (large chest skin injuries, infections, etc.), pneumothorax, mediastinal emphysema, large pleural effusions; 10.Patients who are to be or have been treated with ECMO; 11.Inability to tolerate prone position; 12.Patients who are participating or have participated in other clinical studies;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation Index;Center of Ventilation(COV); | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of times in prone position;Shunt;Plateau Pressure (Pplat);Dosage of vasopressor drugs;Static Compliance(Cstat);Intrinsic PEEP(PEEPi);Heart Rate;Deadspace;V/Q Matching;Perfusion distribution percentage;Total PEEP(PEEPtot);Incidence of adverse events;Global Inhomogeneity(GI);Driving Pressure(DP);V/Q Mismatching;Central Venous Pressure(CVP);peak airway pressure(Ppeak);Blood Pressure;Ventilation distribution percentage; | — |
Countries
China
Contacts
Public ContactShang You
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed