Reproductive failure
Conditions
Interventions
Control group:No interventional treatment
Trial group:Intrauterine perfusion of autologous decidual-like NK cells
Sponsors
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Eligibility
Sex/Gender
Female
Age
22 Years to 38 Years
Inclusion criteria
Inclusion criteria: 1. Reproductive failure with abnormal endometrial natural killer (NK) cells in menstrual blood; 2. With a clear intention to conceive; 3. Normal ovarian function, or premature ovarian insufficiency with =2 high-quality cryopreserved embryos available for transfer; 4. Endometrial thickness measured by transvaginal ultrasound during the periovulatory period =7 mm; 5. Body mass index (BMI) between 18 kg/m² and 28 kg/m²; 6. Willing to comply with the follow-up plan of this study.
Exclusion criteria
Exclusion criteria: 1. Use of progesterone receptor modulators; 2. One of the couple's chromosomal karyotype abnormalities, with no euploid embryo identified via preimplantation genetic testing for aneuploidy; 3. Severe endometriosis or adenomyosis, uterine fibroids affecting uterine cavity morphology, uterine malformations, intrauterine adhesions, or thin endometrium; 4. Uncontrolled autoimmune or endocrine disorders; 5. Contraindications to pregnancy; 6. History of malignant tumors; 7. Participating in other clinical studies; 8. Allergy to blood products.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement rate of NK cells in menstrual blood;Clinical pregnancy rate;Miscarriage rate;Preterm birth rate;Live birth rate; | — |
Countries
China
Contacts
Public ContactHu Yali
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Outcome results
None listed