pain
Conditions
Interventions
Group OL:Intravenous injection of oxycodone 0.05 mg/kg before anesthesia induction.
Group OM:Intravenous injection of oxycodone 0.1 mg/kg before anesthesia induction.
Group OH:Intravenous injection of oxycodone 0.15 mg/kg before anesthesia induction.
Group S:Intravenous injection of sufentanil 0.1 µg/kg before anesthesia induction.
Group N:Intravenous injection of an equal volume of saline before anesthesia induction.
Sponsors
The Second Affiliated Hospital of Shantou University Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for tracheal intubation under general anesthesia for thoracoscopic wedge resection of the lung. 2. Age 18 to 65 years, regardless of gender. 3. Body mass index (BMI) between 18 kg/m² and 30 kg/m². 4. ASA classification I to II. 5. Voluntarily signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of chronic pain. 2. Presence of severe cardiovascular diseases. 3. Presence of severe respiratory diseases or other serious systemic conditions. 4. History of gastrointestinal bleeding or peptic ulcer disease within the past 2 months. 5. Dependence on alcohol or opioid drugs. 6.Long-term use of other psychiatric medications. 7.Allergy to any of the medications used in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative VAS score changes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of inflammatory factors IL-6, IL-10, and TNF-a;Use of rescue analgesics;Ramsay sedation scale;Recovery time;Incidence of adverse reactions;Postoperative pulmonary complications;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactYongfa Zhang
The Second Affiliated Hospital of Shantou University Medical College
Outcome results
None listed