Rosacea
Conditions
Interventions
Simple rosacea skin type group:None
Rosacea with manifestations on both the skin and the eyes group:None
Only ocular meibomian gland dysfunction (MGD) group:None
Sponsors
Bejing Tongren Hospital, Capital Medical Uniersity
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily participate in this clinical study and sign the informed consent form; 2. No gender restriction, age between 18 and 70 years old; 3. (1) Rosacea with only skin involvement group: skin manifestations meet the diagnostic criteria for rosacea; (2) Rosacea with both skin and ocular involvement group: skin manifestations meet the diagnostic criteria for rosacea, and ocular findings confirmed by an ophthalmologist meet the criteria for ocular rosacea; (3) Meibomian gland dysfunction only group: no skin disease, and ocular findings confirmed by an ophthalmologist meet the criteria for meibomian gland dysfunction; (4) Healthy control group: no skin disease and no ocular disease.
Exclusion criteria
Exclusion criteria: 1. Use of systemic medications within the past 3 months, or topical antibiotics, antiparasitic, or anti-inflammatory steroid treatments within the past 2 weeks; 2. Presence of other skin diseases on the face besides rosacea, or currently using other treatments for rosacea; 3. Patients with other systemic diseases that make them unsuitable for enrollment (such as confirmed gastrointestinal diseases (e.g., IBD), autoimmune diseases, tumors, uncontrolled hypertension or diabetes, etc.); 4. Pregnant or breastfeeding women; 5. Patients who have smoked within the past 3 months or consumed alcohol within the past week (excluding chronic alcoholics); 6. Patients with significant abnormalities observed under slit-lamp examination and/or deemed by the investigator to potentially affect the assessment of eyelid margin inflammation-related indicators, including ocular trauma or history of ocular trauma, eyelid anatomical abnormalities, etc.; 7. Patients who have received local treatments on the eyes with tea tree oil, okra eye patches, or hypochlorous acid within the past 2 weeks, or those with a history of intraocular surgery or trauma. Patients who have worn contact lenses or used corticosteroid or antibiotic eye drops in the past month; 8. Used eyelid cleaning products (e.g., eyelid cleansing solution) within 2 weeks, or unwilling to discontinue use of eyelid cleaning products during the study. Used false eyelashes, eyelash extensions, or other cosmetic eyelash or eyelid procedures (e.g., eyeliner tattooing, eyelash tinting, eyelash perming, etc.) within 1 week, or unwilling to discontinue use during the study; 9. Received intense pulsed light (IPL) treatment, such as optimized pulse technology (OPT) or intense regulated pulsed light (IRPL) within 2 weeks, or unwilling to discontinue these treatments during the study; 10. Active eye allergies or ocular or systemic infections (bacterial, viral, or fungal), including fever. Conditions that may, or are deemed by the investigator to, pose significant risk to the subject, confound trial results, or severely interfere with the subject’s participation in the study (including language barriers). Presence of ocular or periocular malignant tumors; 11. Patients who have not signed the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Meibomian gland function, secretion capacity and nature score;Skin Quality of Life Score (DQLI Score);OSDI;The severity of rosacea lesions;Microscopic examination of Demodex eyelashes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tear film lipid layer thickness;Corneal fluorescence staining score;TMH /tear meniscus height;Schirmer test under non-anesthetic conditions;Facial mite examination;Eyelid margin physical sign score;breakup time of tear film; | — |
Countries
China
Contacts
Public ContactTao Rong
Bejing Tongren Hospital, Capital Medical Uniersity
Outcome results
None listed