Meningitis, Ventriculitis
Conditions
Interventions
Group CZA:Receive treatment with ceftazidime-avibactam injection for 14-21 days, with the final course determined by the investigator based on the patients clinical condition. The treatment duration f
Sponsors
Huashan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Eligible participants were aged 18–80 years, male or female. 2. Meningitis or ventriculitis due to carbapenem-resistant Enterobacteriaceae which is susceptible to ceftazidime-avibactam. 3. Those who understand the compliance with the study procedures and methods, voluntarily participate in this study, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.History of allergy to ß-lactam antimicrobials including cephalosporins, ß-lactamase inhibitor-containing cephalosporin complexes, or ceftazidime avibactam sodium for injection and its excipients. 2. Patients who refuse or are unable to collect cerebrospinal fluid, undergo continuous cerebrospinal fluid drainage (including intraventricular drainage or lumbar drainage, etc.) for cerebrospinal fluid collection and drug concentration testing. 3. Patients who have received treatment with ceftazidime-avibactam before enrollment. 4. Patients who require ECMO therapy for respiratory failure or irreversible myocardial dysfunction, etc. 5. Patients who require CRRT therapy. 6. Female patients currently in pregnancy or lactation. 7. Human immunodeficiency virus (HIV) antibody positive. 8. Any person with a physical or psychological disease or condition that, in the judgment of the investigator, is likely to increase the risk of the trial, affect the patient's compliance with the protocol, or interfere with the patient's ability to complete the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood parameters (PK);CSF parameters (PK);Clinical response ; | — |
Countries
China
Contacts
Public ContactJin Hu
Huashan Hospital Fudan University
Outcome results
None listed