Postoperative Analgesia
Conditions
Interventions
Group A(Oliceridine Group):Preparation of postoperative analgesia intravenous pump using Oliceridine at 0.3 mg/kg
Group S(Sufentanil Group):Preparation of postoperative analgesia intravenous pump using Sufentanil at 0.15ug/kg
Sponsors
Weifang People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1. Aged 65–95 years, heart rate 60–100 beats per minute, BMI 18.5–23.9 kg/m²; 2. American Society of Anaesthesiologists (ASA) physical status classification II–III; 3. Patients scheduled for hip replacement surgery under spinal anaesthesia; 4. Generally good physical condition with no underlying medical conditions or well-controlled underlying conditions; 5. Frailty Scale score =3 points.
Exclusion criteria
Exclusion criteria: 1. Severe haematological, circulatory, or respiratory disorders, as well as substantial renal lesions; 2. Allergy to any administered medication; 3. Poorly controlled underlying medical conditions; 4. Long-term use of psychotropic drugs or severe consciousness impairment; 5. History of alcohol abuse, drug use, or substance misuse; 6. Non-cooperation from the patient or their family; 7. Contraindications to nerve block; 8. Contraindications to spinal anaesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite incidence of adverse reactions within 48 hours (including respiratory depression, anxiety, headache, dizziness, nausea, vomiting, constipation, and pruritus).; | — |
Secondary
| Measure | Time frame |
|---|---|
| sedation level;pain level;cognitive function;comprehensive analgesic effect evaluation;quality of recovery; | — |
Countries
China
Contacts
Public ContactLiu Zhenguo
Weifang People's Hospital
Outcome results
None listed