Awake endotracheal intubation
Conditions
Interventions
Remazolam besylate 0.1 mg/kg group:Different concentrations of afentanil (50-110)ng/ml
Remazolam besylate 0.15mg/kg group:Different concentrations of afentanil (40-90)ng/ml
Remazolam besylate 0.2mg/kg group:Different concentrations of afentanil (30-80)ng/ml
Remazolambesylate 0.25mg/kg group:Different concentrations of afentanil (30-80)ng/ml
Remazolam besylate 0.3mg/kg group:Different concentrations of afentanil (20-70)ng/ml
Remazolam besylate 0.35mg/kg group:Different concentrations of afentanil (20-70)ng/ml
Sponsors
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. There was no predictable difficult airway, Mallampati grades ? to II; 2. Deviation from the ideal weight <=25%; 3. Aged 18-64 years; 4. American Society of Anesthesiologists ASA Class I-II; 5. Informed consent, voluntary participation in the experiment, and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with head and neck lesions (including malignancies, prior surgery or radiotherapy), limited mouth opening, limited neck extension, obstructive sleep apnea, moropathic obesity, and progressive airway injury; 2. Relative contraindications: patients with respiratory diseases, allergies to local anesthetics, airway bleeding, and uncooperation; 3. Patients with a known allergy to remazolam besylate or benzodiazepines; 4. Patients with a known allergy to afentanil or opioids; 5. The body weight exceeds the ideal body weight by ±25%; 6. Patients with abnormal coagulation function, endocrine diseases or other effects on hemodynamic status; 7. Patients with a history of drug and alcohol dependence; 8. Patients considered unsuitable for this study by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Airway condition;Tracheal Intubation response;Body movement in tracheal intubation;RASS score during tracheal intubation;Hemodynamic indicators during tracheal intubation;Satisfaction with the anesthesia plan; | — |
Countries
China
Contacts
Public ContactQiaoqiao Xu
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University
Outcome results
None listed