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A study on a dynamic prediction model for the prognosis risk of sepsis-related acute respiratory distress syndrome based on interpretable machine learning and metabolomics

A study on a dynamic prediction model for the prognosis risk of sepsis-related acute respiratory distress syndrome based on interpretable machine learning and metabolomics

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500112406
Enrollment
Unknown
Registered
2025-11-13
Start date
2025-11-13
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

Death group:NA

Sponsors

Yancheng First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Age over 18 years old; (2) Diagnosed with sepsis (diagnosis conforms to the SEPSIS 3.0 criteria); (3) Complicated with acute respiratory distress syndrome (diagnosis conforms to the Berlin definition based on PaO2/FiO2 <= 300 mmHg); (4) Written consent to participate in this study and consent to provide samples for metabolomics testing.

Exclusion criteria

Exclusion criteria: (1) Age > 80 years; (2) Has a history of chronic heart disease, liver and kidney diseases; (3) Pregnant or lactating women; (4) Has severe primary diseases such as cardiovascular, liver, kidney and hematopoietic system disorders; (5) Has immunodeficiency, uses immunosuppressants after organ transplantation, or has autoimmune diseases; (6) Has a tumor or has received chemotherapy within the last month; (7) Has drug-induced pneumonia; (8) The patient or the patient's family refuses to participate in the study; (9) Lost to follow-up during the follow-up period.

Design outcomes

Primary

MeasureTime frame
metabonomics;Receiver Operating Characteristic (ROC) curve;

Countries

China

Contacts

Public ContactLi Xing

Yancheng First People's Hospital

lixing2636@126.com+86 136 0510 0840

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026