Acute lung injury
Conditions
Interventions
No lung injury group:None
Sponsors
Fuzhou University Affiliated Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-80 years; 2.Diagnosed with esophageal cancer and scheduled for thoracoscopic/laparoscopic esophagectomy; 3.Underwent single-lung ventilation during surgery; 4.Received ICU monitoring for >=12 hours postoperatively; 5.Signed informed consent (patient or legal representative);
Exclusion criteria
Exclusion criteria: 1.Preoperative lung infection or radiation pneumonitis; 2.Interstitial lung disease; 3.ARDS within 6 months or acute respiratory failure with invasive mechanical ventilation within 6 months; 4.A clear history of lung cancer and surgical treatment; 5.Major intraoperative complications that make it impossible to complete the planned surgical plan, such as massive intraoperative bleeding requiring emergency treatment, intraoperative cardiac and respiratory arrest, or severe organ damage caused by surgery; 6.Unplanned intraoperative treatment of the lungs, such as bullectomy or wedge resection of a pulmonary nodule.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary bacterial flora and metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| Left and right lung ventilation ratio;inflammatory factors;Epithelial and endothelial injury markers;Oxidative stress markers; | — |
Countries
China
Contacts
Public ContactBaosong Xie
Fuzhou University Affiliated Provincial Hospital
Outcome results
None listed