mild cognitive impairment
Conditions
Interventions
Treatment group of Yizhi Tongluo combined with cognitive digital therapy:Yizhi Tongluo prescription treatment with cognitive digital therapy
YiZhiTongLuoFang treatment group:Yizhi Tongluo prescription treatment with fake cognitive digital therapy
Cognitive digital therapy treatment group:Cognitive digital therapy with placebo
Placebo control group:Placebo combined with false cognitive training
Sponsors
Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 40 and 80 years; 2. Reported cognitive decline in memory or other cognitive domains by the patient or caregiver lasting at least 3 months; 3. Mental status examination (MMSE) score >=20 (primary school) or >=24 (junior high school or above), Montreal Cognitive Assessment (MoCA) score =6 years; 5. Normal or mildly impaired activities of daily living.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with any type of dementia; 2. Individuals with severe mental illness or neurodevelopmental delays; 3. Suffering from other neurological diseases that may impair brain function (such as epilepsy, intracranial tumors, Parkinson's disease, metabolic disorders, encephalitis, multiple sclerosis, traumatic brain injury, normal pressure hydrocephalus, etc.); 4. Cognitive impairment caused by other systemic diseases: such as liver dysfunction, renal dysfunction, thyroid disorders, severe anemia, folic acid and vitamin B12 deficiency, carbon monoxide poisoning, specific infections (such as syphilis, HIV), alcohol and drug abuse, etc.; 5. Severe kidney or liver disease, cancer, or serious illnesses; 6. Use of anti-dementia medications (such as cholinesterase inhibitors, NMDA receptor antagonists, etc.) and anti-vascular cognitive impairment drugs within the past month; 7. Unable to cooperate with completing digital therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum Mental State Examination;Auditory Verbal Learning Test;Boston Naming Test;Trail Making Test-B;36-Item Short Form Survey;Patient Health Questionnaire-9;Symptom scoring in traditional Chinese medicine; | — |
Countries
China
Contacts
Public ContactLi Qianqian
Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University
Outcome results
None listed