Postoperative fatigue
Conditions
Interventions
Experimental group:Intraoperative infusion of low-dose esketamine
Control group:Intraoperative infusion of an equivalent volume of normal saline
Sponsors
The Third Affiliated Hospital of Southern Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Meet the indications for gynecological laparoscopic surgery; 2.Age 18–65 years; 3.ASA classification I or II; 4.No significant preoperative psychiatric abnormalities;
Exclusion criteria
Exclusion criteria: 1.Patients with ASA classification III or higher; 2.History of unstable angina or myocardial infarction within the past 3 months; 3.Contraindications or allergies to the trial drugs or other anesthetics, including untreated or inadequately treated hyperthyroidism, uncontrolled or untreated hypertension (resting blood pressure >180/100 mmHg); 4.Patients with congestive heart failure; 5.Significant preoperative liver or kidney dysfunction; 6.Increased intracranial pressure or central nervous system injury/disease; 7.Body mass index (BMI) 30 kg/m^2; 8.Participation in other clinical trials within one month before the start of this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Fatigue Incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh sleep quality index,PSQI;QoR-15 (Quality of Recovery-15) Score;Visual Analogue Scale (VAS);The incidence of adverse reactions;Intraoperative consumption of etomidate and remifentanil;Steward score after extubation; | — |
Countries
China
Contacts
Public ContactSong Fuhu
The Third Affiliated Hospital of Southern Medical University
Outcome results
None listed