None
Conditions
Interventions
Young Male group (YM group):Ciprofol injection was administered intravenously at an initial dose of 0.4 mg/kg.
Young Female group (YF group):Ciprofol injection was administered intravenously at an initial dose of 0.4 mg/kg.
Older Male group (OM group):Ciprofol injection was administered intravenously at an initial dose of 0.3 mg/kg.
Older Female group (OF group):Ciprofol injection was administered intravenously at an initial dose of 0.3 mg/kg.
Sponsors
Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) According to the new gender and World Health Organization (WHO) human age classification standards, the patients were divided into the young male intubation group (YM group), the middle-aged and elderly male group (OM group), the young female intubation group (YF group), (2) classified by the American Society of Anesthesiologists (ASA) as grades I-II; (3) Body Mass Index (BMI) >= 18 and =60 and = 90 mmHg and = 60 mmHg and = 95%; (5) No difficult airway.
Exclusion criteria
Exclusion criteria: (1) Patients with contraindications to general anesthesia; (2) Patients who require additional anesthesia methods in addition to general anesthesia; (3) Patients with a history of cardiovascular system, respiratory system, nervous system, or gastrointestinal diseases, or who had a history of alcohol abuse or drug abuse within three months before the surgery; (4) Patients allergic to the excipients in propofol injection and etomidate injection, as well as various anesthetic drugs; (5) Patients whose preoperative assessment has determined that they have a difficult airway or a risk of intubation; (6) Patients who used any hypnotic, anesthetic, analgesic, or muscle relaxant drugs before the surgery; (7) Patients who are judged to be unsuitable for inclusion for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of time to maintain MOAA/S 3-4 points, MOAA/S 1-2 points, and MOAA/S=5 points to the entire study dosing time;;The time from initiation of intravenous bolus loading dose to the first MOAA/S<4, and the proportion of subjects with MOAA/S<4 within 3 minutes;Proportion of subjects receiving salvage sedation; | — |
Countries
China
Contacts
Public ContactChen Mi
Affiliated Hospital of Guizhou Medical University
Outcome results
None listed