Degenerative Mitral Regurgitation
Conditions
Interventions
VKA group:Postoperative oral administration of warfarin, initiated at 2.5 mg once daily (QD), with subsequent dose adjustments guided by INR monitoring to maintain a target INR range of 1.8–2.5.
Non-VKA group:Patients in the VKA group will receive enteric-coated aspirin at a maintenance dose of 20 mg orally once daily for three consecutive months postoperatively
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with isolated degenerative mitral regurgitation at West China Hospital of Sichuan University, aged over 18 years, and scheduled to undergo isolated mitral valve repair. 2. All patients underwent preoperative cardiac function assessment and echocardiography. Preoperative cardiac function (NYHA classification) was Class I–III, and all patients had red blood cell and platelet counts within normal ranges.
Exclusion criteria
Exclusion criteria: 1. Patients aged 70 years or older. 2. Patients with a history of stroke, transient ischemic attack (TIA), atrial fibrillation, deep vein thrombosis (DVT), pulmonary embolism, or gastrointestinal or genitourinary bleeding. 3. Patients with severe hepatic or renal dysfunction. 4. Patients who developed post-cardiac surgery complications, including cerebral infarction, transient ischemic attack, atrial fibrillation, or major bleeding events. 5. Patients with left atrial enlargement and/or heart function classified as NYHA Class III or higher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of thromboembolic events;Incidence of major bleeding events; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality;Rehospitalization rate;Reoperation rate (valve-related complications);NYHA functional class change;Left ventricular ejection fraction (LVEF); | — |
Countries
China
Contacts
Public ContactLiang Weitao
West China Hospital, Sichuan University
Outcome results
None listed