Depressive disorder
Conditions
Interventions
10Hz rTMS group :10Hz repetitive transcranial magnetic stimulation
Sponsors
The Affiliated Brain Hospital, Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria for major depressive disorder (MDD) according to the DSM-V; 2. A total score of >=17 on the 17-item Hamilton Depression Rating Scale (HAMD-17); 3. Aged 13 to 17 years, with at least 6 years of formal education; 4. First episode of depression, with no prior systematic treatment with antidepressants or antipsychotics; 5. Han Chinese ethnicity and right-handed; 6. Comprehend the study procedures and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of severe physical or organic brain disorders, or traumatic brain injury; 2. History of physical treatments such as electroconvulsive therapy, repetitive transcranial magnetic stimulation, transcranial direct current stimulation, or transcranial alternating current stimulation (tACS) within the past 6 months; 3. History of substance, alcohol, or psychoactive substance abuse; 4. Presence of metal implants in the body, such as a cardiac pacemaker; 5. Prior to or during treatment, a score >1 on item 4 ("To what extent have you had active suicide ideation?") or item 5 ("To what extent have you had passive suicidal ideation, i.e., wished to die without actively doing anything?") of the Beck Scale for Suicide Ideation (SSI).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antidepressant relief rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effect;Neurocognitive function; The concentrations of oxygenated hemoglobin; | — |
Countries
China
Contacts
Public ContactZheng Wei
The Affiliated Brain Hospital, Guangzhou Medical University
Outcome results
None listed