MASLD
Conditions
Interventions
Nutrition Intervention Group:Provide nutritional meal packs
Time-restricted eating+Nutrition Intervention Group:Nutrition Intervention and time-restricted eating
Sponsors
Wuhan University
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Age 20-60 years; (2) BMI between 24 kg/m² and 40 kg/m²; (3) Diagnosis of fatty liver (confirmed by MRI-PDFF with hepatic fat fraction =5%);
Exclusion criteria
Exclusion criteria: (1) Concurrent with other chronic liver diseases (e.g., hepatitis B or C, autoimmune hepatitis, chronic cholestatic liver disease) or use of medications with potential hepatotoxicity (such as tamoxifen, methotrexate, valproic acid, systemic corticosteroids); (2) Presence of severe cardiac, cerebral, or renal diseases, or liver cirrhosis; (3) History of eating disorders or significant recent weight fluctuations; (4) Currently pregnant, breastfeeding, or planning to become pregnant within the next six months; (5) Currently participating in a weight loss or weight management program; (6) Suffering from claustrophobia or having implanted medical devices (e.g., cardiac pacemakers, metallic implants, or devices with ferromagnetic properties) that preclude magnetic resonance imaging (MRI) examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hepatic Fat Content; | — |
Secondary
| Measure | Time frame |
|---|---|
| Abdominal MRI;weight;BMI;Waist circumference;Hip circumference;body composition;Blood pressure;Pulse rate;Blood glucose;Blood lipids;Liver function;Metagenomics;Metabolomics;Proteomics;Transient Elastography;Transcriptome; | — |
Countries
China
Contacts
Public ContactShuang, Rong
Wuhan University
Outcome results
None listed