Parkinson's disease.
Conditions
Interventions
Gold Standard:Comprehensive Diagnostic Conclusion from Multiple Experts Based on Various Diagnostic Criteria.
Index test:Based on a quantitative evaluation method that incorporates innovative action paradigms, fusion perception, and artificial intelligence, combined with the levodopa shock test
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with clinically established Parkinsonian syndrome according to the 2015 International Movement Disorder Society (MDS) diagnostic criteria for Parkinson's disease; 2. Newly diagnosed (disease duration <3 years) with no prior standardized levodopa therapy; 3. Aged 18–80 years (inclusive), regardless of gender; 4. Willing to undergo study-related evaluations and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe cognitive impairment making assessment difficult; 2. Unable to undergo levodopa challenge test; 3. Severe organ failure (heart, lung, liver, kidney, etc.), malignant tumors, unstable conditions, or other serious medical issues; 4. Severe behavioral or mental disorders; 5. Unable to consent to the study; 6. Other situations where the investigator deems participation unsuitable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Negative Predictive Value for early diagnosis;Specificity for early diagnosis;Accuracy for early diagnosis;Sensitivity for early diagnosis;Positive Predictive Value for early diagnosis;Diagnostic Odds Ratio for early diagnosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive Predictive Value for differential diagnosis;Negative Predictive Value for differential diagnosis;Accuracy for differential diagnosis;Specificity for differential diagnosis;Sensitivity for differential diagnosis;Diagnostic Odds Ratio for differential diagnosis; | — |
Countries
China
Contacts
Public ContactTao Feng
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed