Obesity
Conditions
Interventions
Control group (Group C):Nebulized inhalation of 5ml physiological saline solution
Pentachloroquine hydrochloride group (PHC group):Nebulized inhalation of 0.5mg of pentachloroquine hydrochloride (diluted to 5ml with physiological saline)
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years; 2. ASA (American Society of Anaesthesiologists) physical status classification II–III; 3. Body Mass Index (BMI) >=35 kg/m²; 4. Sleep apnoea and hypopnoea index (AHI) >=15 events per hour; 5. Patients undergoing elective laparoscopic sleeve gastrectomy; 6. No history of drug allergies or abnormal anaesthesia; 7. Tracheal tube removal planned to occur in the operating theatre.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of ALI/ARDS within the past three months, those with severe pulmonary dysfunction (SpO2 = 3), or rapid arrhythmias; 3. Patients with severe hepatic or renal impairment (requiring renal replacement therapy, Child-Pugh class C); 4. Patients with moderate to severe symptomatic prostatic hypertrophy or narrow-angle glaucoma; 5. Patients who have used inhaled beta-2 agonists, anticholinergic drugs, and/or glucocorticoids within one month prior to surgery; 6. Patients who have participated in other drug trials within one month prior to surgery; 7. Patients unable to cooperate with inhalation therapy; 8. Known hypersensitivity to propofol hydrochloride; 9. Patients planned for transfer to the ICU post-operatively; 10. Patients refusing to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area Under the Curve (AUC) of Driving Pressure (DP) at 5 minutes after pneumoperitoneum (T1), 20 minutes after pneumoperitoneum (T2), 35 minutes after pneumoperitoneum (T3), and at the end of pneumoperitoneum (T4).; | — |
Secondary
| Measure | Time frame |
|---|---|
| Airway peak pressure;Area under the airway peak pressure curve;Dynamic lung compliance ;Area under dynamic lung compliance curve;Alveolar arterial oxygen pressure difference (A-aO2);Alveolar arterial oxygen pressure difference (A-aO2);The incidence of postoperative 48 hour hypoxemia;Pulmonary ultrasound score(LUS);Incidence of atelectasis;Adverse reaction rate;Oxygenation index (OI);Oxygenation index (OI);Serum SP-A concentration;Serum SP-A concentration; | — |
Countries
China
Contacts
Public ContactGuo Qiongmei
The First Hospital of Hebei Medical University
Outcome results
None listed