Extubation response and respiratory function during anesthesia recovery and extubation
Conditions
Interventions
Experimental group (SIMV):The experimental group (group S) was given SIMV mode of two-lung ventilation (TLV) immediately after drug withdrawal: FiO2 was 60%, tidal volume was 8ml/kg, frequency was 12-
Control group (VCV):The control group received two-lung ventilation with VCV mode, FiO2 was 60%, oxygen flow was 2L/min, tidal volume was 8ml/kg, respiratory rate was 12-16 times /min, I:E=1:2. The re
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists grade II-III; 2. Both sexes, aged from 18 to 65 years old; 3. body mass index (BMI) : 18.5-24.9 kg/m^2; 4. There were no obvious abnormalities in heart, brain, lung and endocrine function before operation.
Exclusion criteria
Exclusion criteria: 1. Preoperative mental disorders and inability to cooperate with patients; 2. There were anatomical abnormalities of the respiratory tract before operation; 3. Patients with preoperative asthma, chronic obstructive pulmonary disease, pulmonary infection and upper respiratory tract in the last two weeks; 4 Uncontrolled severe hypertension before surgery (SBP > 180 mmHg, DBP > 100 mmHg at rest); 5. Patients who were allergic to anesthetic drugs during operation or did not follow the established anesthesia scheme; 6. Patients with unexpected difficulty in intubation and ventilation of double-lumen bronchial tube during operation; 7. Intraoperative conversion to thoracotomy; 8. Patients with SpO2 < 95% (FiO2 100%) before setting the ventilation mode during the recovery period; 9. Patients with severe hemodynamic fluctuations requiring vasoactive drug intervention before setting ventilation mode during recovery period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and classification of cough during extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure;Diastolic blood pressure;Mean arterial pressure;Heart rate;Pulse oximetry;Partial pressure of oxygen;Carbon dioxide partial pressure;Index of oxygenation;Incidence of man-machine confrontation;Incidence of agitation and RASS score;The time of spontaneous breathing;Time to extubation;Length of PACU stay;Aldrete quality of recovery score;VAS score; | — |
Countries
China
Contacts
Public ContactHongxing Min
General Hospital of Ningxia Medical University
Outcome results
None listed