Intraoperative Pain Management for Osteoporotic Spinal Compression Fractures in the Elderly
Conditions
Interventions
Dexmedetomidine group (Group D):Inject 5ml of saline intravenously 5 minutes before the surgery.
Dexmedetomidine and Sufentanil Group (DS Group):Administer 5ml of sufentanil containing 0.1 µg/kg intravenously 5 minutes before surgery.
Dexmedetomidine-Nalbuphine Group (DN Group):Administer 5ml of intravenous nalbuphine at 0.1mg/kg 5 minutes before the surgery.
Sponsors
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients undergoing single vertebroplasty; 2. Age >65 years; 3. ASA class I-III; 4. BMI 18-28 kg/m^2; 5. Signed informed consent
Exclusion criteria
Exclusion criteria: 1. Patients unable to complete the scale assessment; 2. History of psychiatric disorders, chronic pain, or alcohol or drug abuse; 3. Severe dysfunction of the heart, lungs, liver, or kidneys (transaminase levels increased by 2 times or more); 4. Allergic to the study drug; 5. Preoperative PaO2 < 60 mmHg or SpO2 < 92%; 6. Participation in another drug clinical trial within the past 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic Blood Pressure;Diastolic Blood Pressure;Mean arterial pressure;Heart rate;Pulse oxygen saturation;Ramsay Sedation Scale;Dosage of vasoactive drugs;Number of times vasoactive drugs are used;3D-CAM Scale;Qor-15;Patient pain satisfaction;Postoperative Pain Satisfaction;Incidence of moderate to severe pain;Adverse reaction; | — |
Countries
China
Contacts
Public ContactCongjie Bi;Naying Su
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)
Outcome results
None listed