Clinical study on the effectiveness of the symptom relief of the non-operative side in patients with bilateral carpal tunnel syndrome treated with unilateral carpal tunnel release

A confused phenomenon in the treatment of bilateral carpal tunnel syndrome—Clinical study and exploration of the mechanism of "reorganize brain, change the hand"

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500112301

Enrollment

Unknown

Registered

2025-11-12

Start date

2024-10-20

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carpal tunnel syndrome

Interventions

Mild to moderate carpal tunnel syndrome (CTS) on the non-operative side in Bilateral CTS patients:Carpal tunnel release

Severe CTS on the non-operative side in Bilateral CTS patients:Carpal tunnel release

Surgical group with unilateral mild and moderate CTS:Carpal tunnel release

Surgical group with unilateral severe CTS:Carpal tunnel release

Non-surgical group with unilateral mild and moderate CTS:Non-surgical treatment

Eligibility

Sex/Gender

All

Age

16 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for the study group: 1. Bilateral carpal tunnel syndrome (CTS), with at least one side presenting moderate to severe CTS symptoms. 2. CTS patients aged between 16 and 75 years old. 3. CTS that has not responded to non-surgical treatment for at least two months. 4. Idiopathic CTS. Inclusion criteria for the control group: 1. Unilateral CTS; 2. Idiopathic CTS; 3. CTS patients aged 16 to 75 years old.

Exclusion criteria

Exclusion criteria: Exclusion criteria for the study group: 1. CTS caused by inflammatory factors, such as gout, diabetes, renal failure, etc. 2. Age less than 16 years old or over 75 years old 3. Unilateral CTS 4. CTS combined with nerve entrapment or injury in other parts of the upper limb 5. Recurrence after CTS surgical treatment 6. Disagree to participate in this study Exclusion criteria for the control group: 1. CTS caused by inflammatory factors, such as gout, diabetes, renal failure, etc. 2. Bilateral CTS 3. Age less than 16 years old or over 75 years old 4. CTS combined with nerve entrapment or injury in other parts of the upper limb 5. Recurrence after CTS surgery 6. Disagree to participate in this study.

Design outcomes

Primary

Measure	Time frame
Levine functional score;Levine Symptom Score;	—

Secondary

Measure	Time frame
Static two-point discrimination on the pulp of the thumb, index finger, middle finger and the radial side of ring finger;	—

Countries

China

Contacts

Public ContactChen Chao

Shenzhen People’s Hospital

ts_chenchao@163.com+86 136 3162 4108

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026