Aging
Conditions
Interventions
Longer Telomere Group:None
Shorter Telomere Group:None
Placebo group:Oral placebo, once daily, for 3 months
Probiotics group:Oral probiotics, once daily, for 3 months
Postbiotic group:Oral postbiotic, once daily, for 3 months
Sponsors
Jingdezhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 55 and 79 years;2. Healthy adults with no diagnosis of severe chronic diseases;3. Non-smokers or former smokers, and non-heavy drinkers, to minimize the impact of other factors on the aging process;4. Participants must undergo a comprehensive health assessment prior to enrollment, including blood tests, electrocardiogram (ECG), etc., to ensure the absence of severe systemic diseases;5. Have not taken laxatives, oral antibiotics, probiotics, or other drugs that may alter the gut microbiota within one month;6. Understand the intervention process and sign the informed consent form (ICF).
Exclusion criteria
Exclusion criteria: 1. Patients with severe chronic diseases such as cardiovascular, renal, or hepatic diseases that may affect the aging process;2. Patients on long-term use of antibiotics, hormones, or other drugs that may disrupt the balance of the gut microbiota;3. Patients allergic to probiotic ingredients;4. Patients with severe unhealthy lifestyles, such as heavy drinking, drug abuse, and other related behaviors;5. Pregnant or lactating women;6. Patients diagnosed and evaluated by clinical physicians as unsuitable for probiotic adjuvant therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aging-related phenotypes;Gut microbiota composition;Gut metabolomic profile; | — |
Countries
China
Contacts
Public ContactMinyan Chen
Jingdezhen Second People's Hospital
Outcome results
None listed