Extracranial Vertebral Artery Stenosis, EVAS
Conditions
Interventions
Best Medical Therapy Group (According to the Chinese Expert Consensus (2024) on Endovascular Treatment of Vertebral Artery Origin Stenosis, best medical therapy includes lipid management and antiplate
Drug-Eluting Stent Group (On the basis of best medical therapy, patients undergo implantation of a rapamycin-eluting (sirolimus-eluting) stent.):None
Sponsors
Xindu District People's Hospital of Chengdu
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Age >= 18 years; 2) Vertebral artery origin stenosis confirmed by CTA, MRA, or DSA, with a stenosis degree >= 50%; 3) The patient or legal representative has signed a written informed consent form and is willing to participate in follow-up.
Exclusion criteria
Exclusion criteria: 1) Non-atherosclerotic stenosis (e.g., arterial embolism, arterial dissection, moyamoya disease, vasculitis, etc.); 2) MRI showing new infarction or large territorial cerebral infarction; 3) Intracranial hemorrhage, brain tumor, or epidural/subdural hemorrhage; 4) Pre-onset modified Rankin Scale (mRS) score > 2; 5) Presence of aneurysm, vascular malformation, thrombus, or tandem stenosis at the target lesion site; 6) Vascular anatomical abnormalities or severe vessel tortuosity; 7) Myocardial infarction or major surgery within the past month; 8) Severe allergy to antiplatelet agents, anesthetics, or contrast media; 9) Recent gastrointestinal bleeding, active peptic ulcer, bleeding tendency, or coagulation disorders; 10) Uncontrolled severe hypertension; 11) Severe hepatic or renal dysfunction; 12) Dementia or psychiatric disorders that prevent cooperation or informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of stroke / transient ischemic attack ;intracranial hemodynamic parameters ;During model training/validation (after cross-validation and internal/external validation) and at follow-up endpoints for final validation.; | — |
Countries
China
Contacts
Public ContactGuo Lei
Xindu District People's Hospital of Chengdu
Outcome results
None listed