Atrial septal defect
Conditions
Interventions
Bupivacaine Liposome Group:Ultrasound-guided unilateral thoracic paravertebral nerve block using bupivacaine liposomes
Ropivacaine hydrochloride group:Ultrasound-guided unilateral thoracic paravertebral nerve block using ropivacaine hydrochloride
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Elective thoracoscopic off-pump direct repair of atrial septal defect (ASD) or ASD repair combined with tricuspid valvuloplasty, ASD repair combined with correction of anomalous pulmonary venous drainage; 2. Age 18-55 years, any gender; 3. ASA classification II or III; 4. New York Heart Association (NYHA) functional class II or III; left ventricular ejection fraction (EF) >50%; 5. Postoperative ICU admission; 6. Planned hospital stay >24 hours after surgery.
Exclusion criteria
Exclusion criteria: 1. Refusal to participate; 2. Contraindications for paravertebral nerve block (thoracic infection; infectious disease of the skin or soft tissue at the puncture site, or tumor; unclear or abnormal anatomical location at the puncture site, or unclear surface markings; coagulation disorders; allergy to local anesthetics); 3. Long-term use of chronic pain medications; 4. History of cardiac surgery or previous cardiac surgery; 5. Emergency surgical patients; 6. History of chronic lung disease, with oxygen saturation <90% without supplemental oxygen; 7. Severe liver dysfunction (liver enzymes more than 3 times the upper limit of normal and serum albumin concentration below the reference range); 8. Severe renal insufficiency requiring preoperative renal replacement therapy; 9. Stroke, schizophrenia, depression, Parkinson's disease, epilepsy, or dementia; 10. Illiteracy, speech disorders, or severe hearing or vision impairment that prevents communication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative myocardial markers and stress indicators ;MAP and HR at different time points in the perioperative period ;Perioperative opioid use ;Postoperative NRS scores ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of postoperative mechanical ventilation ;ICU stay time ;Hospital stay time ;Hospitalization expenses ; | — |
Countries
China
Contacts
Public ContactYu Chen
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed