Post-stroke cognitive impairment, PSCI
Conditions
Interventions
Healthy Control Group:none
Stroke Group:None
Sponsors
Beijing Bo'ai Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Stroke Group:; 1. Patients with acute stroke, medically confirmed by MRI/CT (complete imaging data available), admitted to the hospital at 4-6 weeks post-stroke onset; 2. All participants are right-handed; Healthy Control Group:; 1. Age- and gender-matched healthy volunteers, Completed Mini-Mental State Examination (MMSE) assessment, with an MMSE score >= 27 (adjusted for educational level where applicable); 2.All participants are right-handed;
Exclusion criteria
Exclusion criteria: Stroke Group: 1. Patients with aphasia , severe hearing or visual impairment; 2. Patients with pre-stroke decreased level of consciousness , or pre-existing cognitive impairment due to conditions such as infection, metabolic disorders, or neurodegenerative diseases (e.g., Alzheimer's disease, depression, etc.); 3. Patients severely ill post-stroke with impaired consciousness preventing cooperation with examinations; 4. Patients with dysfunction of major organs (e.g., heart, lung, liver), endocrine disorders, connective tissue diseases, or hematologic diseases; 5. Patients with a history of psychiatric illness or behavioral disorders . Healthy Control Group: 1. Individuals with a history of neurological or psychiatric disorders; 2.Individuals with diseases significantly affecting the cognitive system (e.g., unstable thyroid dysfunction without stabilized treatment , severe diabetes mellitus, etc.); 3.Having severe cardiovascular or respiratory diseases, or liver and kidney dysfunction, malignant tumors, etc; 4. Individuals who are pregnant or lactating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessments using the cognitive function scale ;Levels of serum BDNF, P-Tau181, NfL, and PGP9.5 (UCH-L1) ;Patient demographic data(age, sex/gender, BMI, education level, lifestyle history (history of smoking, history of alcohol consumption), and underlying diseases);Clinical and admission imaging findings for the patient;Length of hospital stay for rehabilitation treatment.; | — |
Countries
China
Contacts
Public ContactWen Xing
Beijing Bo'ai Hospital
Outcome results
None listed